利塞膦酸盐对磷硅酸钙理化及生物性能的影响

doi:10.12068/j.issn.1005-3026.2018.10.029

东北大学学报:自然科学版 ›› 2018, Vol. 39 ›› Issue (10): 1516-1520.DOI: 10.12068/j.issn.1005-3026.2018.10.029

• 生物工程 • 上一篇

利塞膦酸盐对磷硅酸钙理化及生物性能的影响

巩天星，米昊炀，陈亚东，张静淑

(东北大学中荷生物医学与信息工程学院，辽宁沈阳110619)

收稿日期:2017-07-03 修回日期:2017-07-03 出版日期:2018-10-15 发布日期:2018-09-28
通讯作者: 巩天星
作者简介:巩天星(1985-)，男，辽宁沈阳人，东北大学副教授.冯明杰(1971-)，男，河南禹州人，东北大学副教授; 王恩刚(1962-)，男，辽宁沈阳人，东北大学教授，博士生导师.
基金资助:
国家自然科学基金资助项目(51502034); 辽宁省博士启动基金资助项目(201501147); 东北大学基本科研业务费专项资金资助项目(N141903001).国家自然科学基金资助项目(51171041).

Effect of Risedronate on Physicochemical and Biological Properties of Calcium Phosphate Silicate

GONG Tian-xing， MI Hao-yang， CHEN Ya-dong， ZHANG Jing-shu

School of Sino-Dutch Biomedical & Information Engineering， Northeastern University， Shenyang 110169， China.

Received:2017-07-03 Revised:2017-07-03 Online:2018-10-15 Published:2018-09-28
Contact: GONG Tian-xing
About author:-
Supported by:
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摘要/Abstract

摘要： 将利塞膦酸盐(0.5%和1.0%)与含有磷硅酸钙的骨水泥粉末混合后进行水化反应，测定骨水泥固化时间及抗压强度，并分析其载药前后的微观结构变化.通过细胞毒性与基因表达水平检测分析了骨水泥的生物性能.结果表明:在0.5%药物水平下，骨水泥促进成骨细胞增殖与分化效果最佳.药物可延缓骨水泥固化，但骨水泥的气孔率会随之降低且晶体结构会更加紧密.载有利塞膦酸的磷硅酸钙骨水泥具有与松质骨相似的力学强度及良好的生物相容性，作为骨组织修复材料具有很好的应用价值.

关键词: 磷硅酸钙, 利塞膦酸盐, 骨质疏松, 骨水泥, 骨组织修复

Abstract: Risedronate (0.5% and 1.0%) was mixed with bone cement powder containing calcium phosphate silicate for hydration reaction. The curing time and compressive strength of bone cement were measured and the microsturctural changes before and after drug loading were analyzed. The biological properties of bone cement were analyzed by detection of cytotoxicity and gene expression levels. The results showed that the best proliferation and differentiation of osteoblasts were obtained at 0.5% drug level.The drug can delay the curing of bone cement， but the porosity of bone cement decrease and the crystal structure become tighter.The calcium phosphate silicate cement containing risedronate acid has good biocompatibility and the mechanical strength similar to cancellous bone， which is prosperous in the application of a bone tissue repair material.

Key words: calcium phosphate silicate, risedronate, osteoporosis, bone cement, bone tissue repair

中图分类号:

TH145.1⁺1

巩天星，米昊炀，陈亚东，张静淑. 利塞膦酸盐对磷硅酸钙理化及生物性能的影响[J]. 东北大学学报:自然科学版, 2018, 39(10): 1516-1520.

GONG Tian-xing， MI Hao-yang， CHEN Ya-dong， ZHANG Jing-shu. Effect of Risedronate on Physicochemical and Biological Properties of Calcium Phosphate Silicate[J]. Journal of Northeastern University Natural Science, 2018, 39(10): 1516-1520.

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利塞膦酸盐对磷硅酸钙理化及生物性能的影响

Effect of Risedronate on Physicochemical and Biological Properties of Calcium Phosphate Silicate

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