Abstract: The as-cast and hot rolling microstructures of high-boron steel prepared from vacuum induction furnace were investigated, in which the element B was uniformly distributed. Titanium added into it had a significant effect on decreasing the amount of Fe2B and FeB precipitated at grain boundaries and increasing the distribution of boron within the grain and grain boundaries, with precipitations of TiB2 distributing dispersively and uniformly on ferritic matrix. The hot rolling conditions were determined reasonably by simulation, i.e., the soaking temperature was 1080-1120°C, slab rolling temperature was 1070-1110°C, finish rolling temperature was 810-850°C and pass reduction ratio was 10%-20%. After multi-pass rolling and subsequent air-cooling, the mechanical properties of the high-boron steels were enhanced significantly.