东北大学学报（自然科学版）

东北大学学报(自然科学版) ›› 2011, Vol. 32 ›› Issue (11): 1587-1590.DOI: -

• 论著 • 上一篇    下一篇

无模板法制备三维互联大孔羟基磷灰石

茹红强;楚宝帅;林春青;陈思;   

  1. 东北大学材料与冶金学院;
  • 收稿日期:2013-06-19 修回日期:2013-06-19 发布日期:2013-04-04
  • 通讯作者: -
  • 作者简介:-
  • 基金资助:
    国家高技术研究发展计划项目(2009AA03250);;

Non-templated preparation of 3D-interconnected macroporous hydroxyapatite

Ru, Hong-Qiang (1); Chu, Bao-Shuai (1); Lin, Chun-Qing (1); Chen, Si (1)   

  1. (1) School of Materials and Metallurgy, Northeastern University, Shenyang 110819, China
  • Received:2013-06-19 Revised:2013-06-19 Published:2013-04-04
  • Contact: Ru, H.-Q.
  • About author:-
  • Supported by:
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摘要： 介绍了一种新型的聚乙烯醇凝胶辅助法(PAF)来制备三维互联大孔羟基磷灰石(HA)陶瓷,PAF法不涉及模板剂、造孔剂的使用及复杂化学过程.X射线衍射分析表明:经烧结后的HA组分单一,为纯HA.扫描电子显微镜(SEM)和激光共聚焦显微镜观察结果表明:大孔HA孔结构的联通性和孔径大小可通过控制HA粉及PVA的用量来实现;当PVA与HA质量比为4.4和4.9时制得的大孔HA孔径分布较均匀,所制得大孔HA具有三维互联结构,大孔直径介于90~200μm,较接近人骨的孔尺寸和联通特性,具有潜在的应用价值.

关键词: 无模板法, 大孔, 羟基磷灰石, 三维互联

Abstract: A novel synthesis method, called poly(vinyl alcohol) assisted foaming method (PAF method) for the preparation of porous hydroxyapatite (HA) scaffolds with 3D-interconnected macropores without using any templates or porogens or complicated chemical process was reported. XRD analyses revealed that the sintered macroporous HA is pure in compositions. SEM and CLSM results showed that the macroporous structures and pore sizes can be facilely tuned by adjusting the mass ratios of PVA to HA. The mass ratios PVA to HA of 4.4 and 4.9 produce macroporous HAs with uniformly distributed macropores with sizes ranging from 90 to 200 μm in sizes, which are similar to those of human bone in terms of macropore size and interconnectivity. It is therefore believed that such kind of 3D interconnected macroporous HA scaffolds have great potential for application in the area of bone tissue engineering.

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