基于修订的心室肌细胞模型的短QT综合征病理仿真

doi:10.12068/j.issn.1005-3026.2015.08.008

东北大学学报:自然科学版 ›› 2015, Vol. 36 ›› Issue (8): 1097-1101.DOI: 10.12068/j.issn.1005-3026.2015.08.008

基于修订的心室肌细胞模型的短QT综合征病理仿真

刘纪红^1,2，林杨²，林海叶²

(1. 东北大学信息科学与工程学院，辽宁沈阳110819； 2. 东北大学中荷生物医学与信息工程学院，辽宁沈阳110819)

收稿日期:2014-06-23 修回日期:2014-06-23 出版日期:2015-08-15 发布日期:2015-08-28
通讯作者: 刘纪红
作者简介:刘纪红(1969-)，女，辽宁沈阳人，东北大学副教授.
基金资助:
国家自然科学基金资助项目(61173028).

Pathology Simulation of Short QT Syndrome Based on an Improved Model of Ventricular Myocytes

LIU Ji-hong^{1, 2}， LIN Yang²， LIN Hai-ye²

1. School of Information Science & Engineering， Northeastern University， Shenyang 110819， China; 2.Sino-Dutch Biomedical and Information Engineering School， Northeastern University， Shenyang 110819， China.

Received:2014-06-23 Revised:2014-06-23 Online:2015-08-15 Published:2015-08-28
Contact: LIU Ji-hong
About author:-
Supported by:
-

摘要/Abstract

摘要： 基于已公布的人体心室肌细胞模型数据建立了一维心室肌细胞模型，仿真了伪心电图及心内膜细胞、心中间膜细胞和心外膜细胞这三种细胞的动作电位.基于构建的模型进行周期实验，针对实验中出现的问题修订模型中的参数.将修订后模型的仿真结果与已经公布的实验数据进行对比，从而验证模型修订的合理性和可靠性.最后基于修订的心室肌细胞模型对与KCNJ2有关的短QT综合征的病理情况进行仿真，分析仿真结果，验证了修订模型的实用性.

关键词: 病理仿真, 离子通道, 动作电位时程, 膜电导, 短QT综合征

Abstract: Based on the data of the existing human ventricular cell model， a one-dimensional ventricular cell model is established. The pseudo ECG， action potentials for the endocardium cell， the mid-myocardium cell and the epicardium cell are simulated. The cycle simulation is carried out based on the established model， the parameters in the model are revised according to the problems encountered in the simulation process. It can be seen by comparing the existed experiment data with the simulation results that the improved model is reasonable and reliable. The KCNJ2-correlated short QT syndrome pathological conditions is also simulated by the improved model and the model proposed is validated.

Key words: pathology simulation, ion channel, action potential duration, membrane conductance, short QT syndrome

中图分类号:

R318.11

刘纪红，林杨，林海叶. 基于修订的心室肌细胞模型的短QT综合征病理仿真[J]. 东北大学学报:自然科学版, 2015, 36(8): 1097-1101.

LIU Ji-hong ， LIN Yang， LIN Hai-ye. Pathology Simulation of Short QT Syndrome Based on an Improved Model of Ventricular Myocytes[J]. Journal of Northeastern University Natural Science, 2015, 36(8): 1097-1101.

参考文献

[1]Allah E， Aslanidi O V，Tellez J O，et al.Postnatal development of transmural gradients in expression of ion channels and Ca²⁺-handling proteins in the ventricle［J］.Journal of Molecular and Cellular Cardiology，2012，53(2):145-155.
[2]Maury P，Extramiana F，Sbragia P，et al.Short QT syndrome.update on a recent entity［J］.Archives of Cardiovascular Diseases，2008，101(11):779-786.
[3]Adeniran I，Hancox J C，Zhang H.In silico investigation of the short QT syndrome，using human ventricle models incorporating electromechanical coupling［J］.Frontiers in Physiology，2013，4:1-16.
[4]Adeniran I，El Harchi A，Hancox J C，et al.Proarrhythmia in KCNJ2-linked short QT syndrome:insights from modeling［J］. Cardiovascular Research，2012，94(1):66-76.
[5]Deo M，Ruan Y，Pandit S V，et al.KCNJ2 mutation in the short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia［J］.Proceedings of the National Academy of Sciences of the United States of America，2013，110(11):4291-4296.
[6]ten Tusscher K H W J，Panfilov A V.Alternans and spiral breakup in a human ventricular tissue model［J］.American Journal of Physiology:Heart and Circulatory Physiology，2006，291(3):H1088-H1100.
[7]刘泰槰.心肌细胞电生理学［M］.北京:人民卫生出版社，2005:10-117.(Liu Tai-peng.Myocardial cell electrophysiology［M］.Beijing:People’s Medical Publishing House，2005:10-117.)
[8]ten Tusscher K H W J，Noble D，Panfilov A V，et al.A model for ventricular tissue［J］.American Journal of Physiology:Heart and Circulatory Physiology，2004，286(4):H1573-H1589.
[9]Marban E.Cardiac channelopthies［J］.Nature，2002，415(6868):213-218.
[10]严干新，郭继鸿，崔长琮，等.心律失常的现代治疗［M］.北京:人民卫生出版社，2013:337-343.(Yan Gan-xin，Guo Ji-hong，Cui Chang-cong，et al.Management of cardiac arrhythmias［M］.Beijing:People’s Medical Publishing House，2013:337-343.)
[11]Priori S G，Pandit S V，Rivolta I，et al.A novel form of short QT syndrome(SQT3) is caused by a mutation in the KCNJ2 gene［J］.Circulation Research，2005，96(7):800-807.
[12]El Harchi A，McPate M J，Zhang Y H，et al.Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome［J］.Journal of Molecular and Cellular Cardiology，2009，47(5):743-747.

基于修订的心室肌细胞模型的短QT综合征病理仿真

Pathology Simulation of Short QT Syndrome Based on an Improved Model of Ventricular Myocytes

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价