Journal of Northeastern University Natural Science ›› 2018, Vol. 39 ›› Issue (10): 1516-1520.DOI: 10.12068/j.issn.1005-3026.2018.10.029

• Biologic Engineering • Previous Articles    

Effect of Risedronate on Physicochemical and Biological Properties of Calcium Phosphate Silicate

GONG Tian-xing, MI Hao-yang, CHEN Ya-dong, ZHANG Jing-shu   

  1. School of Sino-Dutch Biomedical & Information Engineering, Northeastern University, Shenyang 110169, China.
  • Received:2017-07-03 Revised:2017-07-03 Online:2018-10-15 Published:2018-09-28
  • Contact: GONG Tian-xing
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Abstract: Risedronate (0.5% and 1.0%) was mixed with bone cement powder containing calcium phosphate silicate for hydration reaction. The curing time and compressive strength of bone cement were measured and the microsturctural changes before and after drug loading were analyzed. The biological properties of bone cement were analyzed by detection of cytotoxicity and gene expression levels. The results showed that the best proliferation and differentiation of osteoblasts were obtained at 0.5% drug level.The drug can delay the curing of bone cement, but the porosity of bone cement decrease and the crystal structure become tighter.The calcium phosphate silicate cement containing risedronate acid has good biocompatibility and the mechanical strength similar to cancellous bone, which is prosperous in the application of a bone tissue repair material.

Key words: calcium phosphate silicate, risedronate, osteoporosis, bone cement, bone tissue repair

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