Abstract: An economic optimization-oriented method of analysis was proposed to determine the optimal output rate and grade of flotation concentrate from a certain hematite mine, thus maximizing the economic benefit. With the NaOH, starch, CaO and RA515 used as reverse flotation agents and lots of flotation tests done, the allowable ranges of dose of different agents were determined, then a regression model was developed through orthogonal tests to determine the concentrate grade, output rate and dose of various agents for flotation. According to the relation between price and concentrate grade, an optimization model was developed and, as a result, the proposed method was used to determine the appropriate concentrate grade and output value, i.e., 61.95% and 61.19%, respectively, by which the max. income per 100 t raw ore came up to RMB 69 thousand yuan. Exemplification result showed that the method proposed is simple and practical.