Abstract: A real estate market has its own periodic fluctuation. Based on the qualitative analysis of the periodic fluctuation of real estate markets at home and abroad and taking the investment in real estate development and the area of the commercial housing being constructed as the input index and the total floor space of commercial housing and sales amount of commercial housing as the output index, the longitudinal analysis (in the same city but different time) and transverse analysis (in the same time but different cities) were both made quantitatively via the data envelopment analysis method (C²R model of DEA) and Lingo mathematical software, where the data were acquired from the periodic fluctuation of real estate market in several cities in China. In this way some policies were envisaged to make advantages of the periodic fluctuation on the basis of existing macro/microscopic policies, thus improving the operational efficiency, i.e., to optimize the invalidity at present.