Abstract: The desulfhurization performance of 5 flotation collectors for high-sulfur bauxite were investigated, i.e. the dodecyl sodium sulfate, ethyl xanthate, ethyl thiocarbamate, butyl xanthate and isobutyl xanthate, where the influence of dose, floating time, pulp density, pH value and ore grain size on the desulfurization rate and alumina flotation recovery were emphasized. The results showed that the dodecyl sodium sulfate has no floatability for desulfhurization, and that of either ethyl xanthate or ethyl thiocarbamate is limited to a certain extent. And the butyl xanthate and isobutyl xanthate both have high floatability for desulfhurization, so they are suitable for industrial applications. The open-circuit experiments of butyl xanthate and isobutyl xanthate showed that the latter has higher selectivity but the former has strong collectability.