Abstract: The prototype of a new tester was proposed and conceptually designed on the basis of the hybridization of gene chips resulting from nucleic acid amplification, which integrates the effects of amplification, hybridization, cleaning and testing together. The simulation software ADAMS was applied to the tester to kinematically simulate the virtual prototype of a robot which is just the core part of the tester. The time response curves of robot's swinging arms with gene chip fitted together were then obtained. By means of the principle of kinematic reliability of mechanisms, the reliability of the robot's motion was analyzed with its kinematic precision calculated. The results indicated that the tester can provide well the kinematic precision for either transverse or longitudinal motion of robot, thus verifying the feasibility of the prototypical tester.