Abstract: The chiral liquid crystal monomer (+)4-(2-acryloyloxy)-ethoxybenzoyloxy-[4'-(2-methyl)-butoxy] biphenyl (AEMBB) was designed and synthesized according to the theory of twist grain boundary (TGB) which can be observed in chiral materials with strong twisting power. The termination of the reaction process can be judged according to the carboxylic acid/hydroxyl peak vanished from the reactant by Fourier transform infrared spectroscopy (FTIR). The implementation of the target chemical structure of the monomer depends on the position of ¹H as determined by the spectroscopy of ¹H nuclear magnetic resonance (NMR). The properties and phase transition of the target monomer were studied by polarizing optical microscopy (POM) and differential scanning calorimetry (DSC), and the results revealed that the monomer is an enantiotropic liquid crystal available to be in cholesteryl, twist grain or chiral smectic C phases.