Abstract: The object-oriented Petri net (OPN) was used to analyze the operation of supply chain in the circumstance of networked manufacturing. In this way the rules of the computer integrated manufacturing open system (CIMOS) were employed to model the operation of manufacturing supply chain. Describing what operations are needed in such a supply chain, the operation mode of supply chain supported by the networked manufacturing center was presented. Then, the OPN model for each and every object was developed to get the P-invariant by which such system defects as deadlock, overflow and conflict can be analyzed. With a manufacturer taken as example, the analysis of OCN-related matrix and P-invariant proved that the model thus designed has favorable performance.