Abstract: The material parameters and stress level have important influence on the fatigue life of aeroengine compressor disk. A detailed calculation was done to determine the sensitivities of fatigue life to related parameters with relevant fatigue life-sensitivity curves given. It was found that the sensitivities to fatigue strength parameters and stress are greater than that to plastic fatigue parameters, among which the sensitivity to fatigue strength exponent is up to 10 as the greatest one. The sensitivity to fatigue ductility coefficient is less than 1, and therefore can be taken as a constant approximately in practical design during which the material, structure and process technology of the disk can all be determined reasonably according to different parameter sensitivities. A reference is thus provided further for the design of reliability and optimization.