Abstract: To confirm the project of regional water resource development in a reasonable way so as to promote relevantly the sustainable economic development, a multi-objective programming model is developed for the optimal distribution of water resource in Songyuan city in view of system engineering, according to the present situation of water resource and future goals. With the aim of utilizing water resource reasonably and efficiently, what are required to do include readjusting and optimizing the industrial mix, reducing the number of sectors consuming too much water and supporting preferentially the industries which consume less water than conventional ones with high water availability and aggregate economic benefits. All these suggest an outlook on effective regional water distribution on the basis combining economic and ecologic conditions with social benefits, thus providing an optimized macro-planning to guide regional utilization of water resource and economic growth. It is of far reaching importance to sustainable economic growth and coordinative utilization of water resource.