Abstract: A Monte Carlo simulation package combining DPM (dose planning method) with Matlab was developed to solve the dose calculation problems in radiotherapy treatment by rewriting the current radiotherapy software DPM and taking advantage of Matlab for profile visualization, thus obtaining easily the isodose distribution curve and isodose surface contour. The package developed are highly potential in practical applications for its speed-up in simulation and evidently visible results, which showed that this method is correct, effective and capable of enhancing the level of radiotherapy.