Abstract: The leak detection and location system for oil pipeline was developed on Visual C++ software platform. Equipments of industrial field and devices of data acquisition were used as hardware platform. The system integrates flow difference detection technology with negative pressure wave location technology. Sample synchronization was solved by GPS in the distributed system, and special point of signals with noise was caught by wavelet transform method. The running curve chart can be displayed on screen. With database technology, the real-time running data can be stored in database in order to query and analyze the cause of fault. The system has superior precision in location in few minutes. Not only the system cost low, but also the system is stable and reliable. The system function can be extended easily. The system can be used both in experiment simulation and in industrial field monitoring.