Abstract: This paper investigated the velocity and turbulence distribution of the cone nozzle jet flow field spraying into a vacuum chamber under different nozzle diameters and injection pressures. The simulations were carried out by using the Fluent software based on the volume of fluid method, the standard k-Ε turbulence model and the PISO (pressure implicit with splitting of operators) arithmetic. The results show that the jet flow and velocity gradient increase with increasing nozzle diameter, and it is helpful to improve jet spray quality with size uniform distribution after jet diffusion and drop breakup. When the nozzle diameter is constant, the jet turbulence intensity distribution achieves the optimum condition within 10~15 MPa, and the flow field is better than that under any other pressures. Compared with chloroform and carbon tetrachloride solvents, acetone shows better flow distribution and atmospheric effect if neglecting the solubility of the polymer materials.