Abstract: The theories of industrial technology innovation strategic alliance were sorted out， and the relationship and significance of industrial technology innovation strategic alliance and regional innovation system were analyzed. Besides， the paper explored such problems of Liaoning industrial technology innovation strategic alliance as the small number of alliances， the poor sense of responsibility of backbone enterprises participating in the construction of alliances， the unsound operating mechanism and the low level of overall alliance construction. It is suggested that the three spiral structures be strengthened， the alliance partnership be optimized， the relationship between different levels of technology research and development be deepened， the findings and risk sharing mechanism be perfected， the relationship between government investment and enterprise investment be coordinated， the relationship between overall interest and individual interest be optimized， the relationship between competition and cooperation be established， the relationship between resources integration and optimal configuration be clarified， the relationship among various alliance modes be coordinated， and the openness and limitation of alliance be ascertained.

Key words: Liaoning, regional innovation system, industrial technology innovation strategic alliance