Abstract: Professor Chen Chang-shu， one of the first-generation scholars of Dialects of Nature in China， began to research scientific and technological methodology in 1950s. At the beginning of his research， he made a clear distinction between scientific methodology and technological methodology. He logically found the independent research value of technological methodology from his exploration of scientific epistemology and methodology， and constantly enriched the research. His thought of scientific and technological methodology is characterized by the following four aspects: firstly， insisting on the fundamental standpoint of Marxism; secondary， the consistency in methodology and epistemology of science and technology; thirdly， the uniqueness of exploring technological methodology based on the distinction between science and technology; fourthly， emphasizing the research of creative methodology of science and technology.

Key words: Chen Chang-shu, scientific methodology, technological methodology