冠脉狭窄对外周与中心动脉间传递函数的影响

doi:10.12068/j.issn.1005-3026.2018.12.006

东北大学学报:自然科学版 ›› 2018, Vol. 39 ›› Issue (12): 1702-1707.DOI: 10.12068/j.issn.1005-3026.2018.12.006

冠脉狭窄对外周与中心动脉间传递函数的影响

张良钰，边天元，徐礼胜

(东北大学中荷生物医学与信息工程学院，辽宁沈阳110169)

收稿日期:2017-08-22 修回日期:2017-08-22 出版日期:2018-12-15 发布日期:2018-12-19
通讯作者: 张良钰
作者简介:张良钰(1993-)，男，山东淄博人，东北大学博士研究生；徐礼胜(1975-)，男，安徽安庆人，东北大学教授，博士生导师.冯明杰(1971-)，男，河南禹州人，东北大学副教授; 王恩刚(1962-)，男，辽宁沈阳人，东北大学教授，博士生导师.
基金资助:
国家自然科学基金资助项目(51171041).国家自然科学基金资助项目 (61773110， 61374015)；中央高校基本科研业务费专项资金资助项目 (N161904002，N130404016).

Influence of Coronary Artery Stenosis on Transfer Function Between Peripheral and Central Arteries

ZHANG Liang-yu， BIAN Tian-yuan， XU Li-sheng

School of Sino-Dutch Biomedical and Information Engineering， Northeastern University， Shenyang 110169， China.

Received:2017-08-22 Revised:2017-08-22 Online:2018-12-15 Published:2018-12-19
Contact: XU Li-sheng
About author:-
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摘要/Abstract

摘要： 观察冠脉狭窄患者中心动脉波的变化，并探讨外周与中心动脉间的传递函数与冠脉狭窄的相关性.采集了9名冠脉狭窄患者支架手术前后的中心动脉与桡动脉脉搏波，分别建立手术前后的自回归传递函数数学模型，并将手术后的桡动脉波形分别用手术前后的传递函数模型重建中心动脉波形.提取两中心动脉波形的特征点并计算重建出的两中心动脉压的特征参数K，t，接着分别与术后实测中心动脉压的参数进行显著性差异分析.实验结果表明，冠状动脉狭窄对传递函数存在着一定的影响，在临床上的意义为对于急性心梗患者在急性患病时间内不能用通用传递函数重建中心动脉.

关键词: 冠状动脉狭窄, 传递函数, 桡动脉波形, 中心动脉波形, 显著性差异分析

Abstract: To observe the changes of central artery wave and explore the correlation between transfer function of peripheral and central artery and coronary artery stenosis in patients. Center artery and radial artery pulse wave before and after stent surgery from 9 patients with coronary artery stenosis were collected. ARX(auto-regressive with extra inputs) transfer function before and after stent surgery were established. Radial artery waveform after surgery was reconstructed with the transfer function model before and after surgery. Characteristic points of the two central arterial waveforms were extracted and the characteristic parameters K and t of the reconstructed two central arterial pressure were calculated. And then， the significant difference analysis of the measured central arterial pressure parameters was analyzed. The experimental results indicated that coronary artery stenosis has a certain impact on the transfer function， and clinical significance of the acute myocardial infarction in patients with acute illness cannot be reconstructed with a common transfer function of the central artery.

Key words: coronary artery stenosis, transfer function, radial artery waveform, central artery waveform, significant difference analysis

中图分类号:

TP391.4

张良钰，边天元，徐礼胜. 冠脉狭窄对外周与中心动脉间传递函数的影响[J]. 东北大学学报:自然科学版, 2018, 39(12): 1702-1707.

ZHANG Liang-yu， BIAN Tian-yuan， XU Li-sheng. Influence of Coronary Artery Stenosis on Transfer Function Between Peripheral and Central Arteries[J]. Journal of Northeastern University Natural Science, 2018, 39(12): 1702-1707.

参考文献

[1]Jia D G，Chao J，Li S，et al.A fiber Bragg grating sensor for radial artery pulse waveform measurement［J］.IEEE Transactions on Biomedical Engineering，2017，65(4):839-846.
[2]Hashimoto J.Central hemodynamics and target organ damage in hypertension［J］.Tohoku Journal of Experimental Medicine，2014，233(1):1-8.
[3]Sharman J E，Marwick T H，Gilroy D，et al.Randomized trial of guiding hypertension management using central aortic blood pressure compared with best-practice care:principal findings of the BP GUIDE study［J］.Hypertension，2013，62(6):1138-1145.
[4]O′Rourke M F.Influence of ventricular ejection on the relationship between central aortic and brachial pressure pulse in man ［J］.Cardiovascular Research，1970，4(3): 291-300.
[5]张晓锋，邵玉玲，张晓波，等.有创中心动脉压与外周动脉压差及其与冠状动脉病变程度的关系［J］.中国介入心脏病学杂志，2013，21(5):301-304.(Zhang Xiao-feng，Shao Yu-ling，Zhang Xiao-bo，et al.The relationship between the pulse pressure differences of central and peripheral measurement with the extent of coronary atherosclerotic lesions ［J］.Chinese Journal of Interventional Cardiology，2013，21(5):301-304.)
[6]倪慧，周鑫斌，邱原刚，等.无创中心动脉压与冠状动脉病变程度及其斑块特征的相关性研究［J］.心电与循环，2017，36(1):9-11.(Ni Hui，Zhou Xin-bin，Qiu Yuan-gang，et al.The association of non-invasive central blood pressure with extent of coronary artery disease and plaque characteristics ［J］.Journal of Electrocardiology，2017，36(1):9-11.)
[7]Alc G，zkan B，Aar G，et al.The relation between aortic pulse pressure and coronary artery disease ［J］.Kosuyolu Kalp Dergisi，2011，14(2):45-50.
[8]Herbert A，Cruickshank J K，Laurent S，et al.Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors ［J］.European Heart Journal，2014，35(44):3122-3133.
[9]Ljung L.System identification［M］//Signal analysis and prediction.Boston:Birkhuser，1998:163-173.
[10]Gallagher D，Adji A，O′Rourke M F.Validation of the transfer function technique for generating central from peripheral upper limb pressure waveform ［J］.American Journal of Hypertension，2004，17:1059-1067.
[11]Chen C H，Nevo E，Fetics B，et al.Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure［J］.Circulation，1997，95(7):1827-1836.
[12]Yao Y，Xu L S，Sun Y X，et al.Validation of an adaptive transfer function method to estimate the aortic pressure waveform ［J］.IEEE Journal of Biomedical & Health Informatics，2016，21:1599-1606.
[13]Pauca A L，O’Rourke M F，Kon N D.Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform ［J］.Hypertension，2001，38(4):932-937.
[14]萧德云，方崇智.系统辨识理论及应用［M］.北京:清华大学出版社，2014:248-267.(Xiao De-yun，Fang Chong-zhi.System identification theory and application ［M］.Beijing:Tsinghua University Press，2014:248-267.)
[15]Sjberg J，Zhang Q，Ljung L，et al.Nonlinear black-box modeling in system identification:a unified overview ［J］.Automatica，1995，31(12):1691-1724.
[16]Fetics B，Nevo E，Chen C H，et al.Parametric model derivation of transfer function for noninvasive estimation of aortic pressure by radial tonometry ［J］.IEEE Transactions on Biomedical Engineering，1999，46(6):698-706.

冠脉狭窄对外周与中心动脉间传递函数的影响

Influence of Coronary Artery Stenosis on Transfer Function Between Peripheral and Central Arteries

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