Abstract: Based on the SEIR model， two compartments for self-protection and isolation are introduced， and a more general infectious disease transmission model is proposed. Through qualitative analysis of the model， the basic reproduction number of the model is calculated， and the local asymptotic stability of the disease-free equilibrium point and the endemic equilibrium point of the model is analyzed through eigenvalue theory and Routh-Hurwitz criterion. The numerical simulation and fitting results of COVID-19 virus show that the proposed SEIQRP model can effectively describe the dynamic transmission process of the infectious disease. In the model， the three parameters， i.e. protection rate， incubation period isolation rate， and infected person isolation rate play a very critical role in the spread of the disease. Raising people’s awareness of self-protection， focusing on screening for patients in the incubation period， and isolating and treating infected people can effectively reduce the spread of infectious diseases.

Key words: infectious disease spread model; self-protection; basic reproduction number; stability; fitting