Abstract: Six nitrones were prepared by using N-methylhydroxylamine sulfate and aromatic carbonyl substances by a synthetic process. Their purity were above 95% by using a suitable recrystallizing method with a yield over 90%. The melting points and ¹H-NMR data of these products were measured with suitable instruments to characterize the chemical structure of these products together with the analysis of H-NMR wave spectrum. The influences of pH values and solvents used on the reaction systems and the purity of products were discussed. The synthetic process is ideal for the synthesis of a series of nitrones because of simple operation, high purity and high yield.