Abstract: Proposes a mathematical model to optimize the location of catastrophic rescue center, taking account of the probability of catastrophic occurrence, catastrophic diffusion function and rescue function. Because the catastrophic diffusion and rescue functions are both nonlinear and time-variable, they are very difficult to be solved by way of common mathematical programming. A heuristic embedded genetic algorithm is therefore developed to solve the special model. The computation of a large number of examples arising from practice provide satisfactory results.