Abstract: The reliable robust control is studied for a class of uncertain switched nonlinear systems disturbed by uncertain structural parameters. It is assumed that the nonlinear terms satisfy the norm-bounded condition and the parameter uncertainty is time-variable. Based on multiple-Lyapunov function method, the design of hybrid state feedback-reliable controllers is given such that the corresponding closed-loop system is globally asymptotically stable for all admissible uncertainties and actuator failures. The simulation result demonstrated the effectiveness of the proposed approaches.