Abstract: According to the idea about constructing a CDC (center for disease control), the deployment and response mechanism of CDC-based benign worms are designed, with the process of using CDC-based benign worms to counteract the propagation of worms modeled and simulated. Then, the two influencing factors on the process are revealed through the simulation, i.e. the response time and detection rate of worm by probe. The propagation model of CDC-based benign worms can provide a better understanding and prediction for the scope and speed of using benign worms countering against the propagation of worms.