Abstract: The borate surfactant SBW-181 was used for the modification experiments of calcium sulphate whiskers on the conditions of individual factors. Influences of the technical factors such as surfactant dosage, modification temperature/time and stirring speed on the surface modification of calcium sulphate whiskers were studied. The modified calcium sulphate whiskers were characterized with activation index, contact angle, SEM and IR spectrum analysis, and the results indicated that the SBW-181 has good effect on surface modification of calcium sulphate whiskers. On the optimum technological conditions, the activation index of modified product is 0.996 with a contact angle of 103.4°. A reaction model was developed relevantly for the whiskers and surfactant, and a conclusion drawn from that plays a role of guidance in the industrialized surface modification of calcium sulphate whiskers as a theoretical reference offered for their applications.