Abstract: Orthogonal testing, including four factors and three levels of each factor, was conducted to optimize preparation conditions for NiFe2O4 matrix inert anode. The effects of these factors on porosity were determined by range analysis and the primary and secondary factors were then analyzed. Porosity of the inert anode was most greatly affected by sintering temperature, followed in succession by nanopowder content, molding pressure, and sintering time. Adding the proper amount of nanopowder while increasing sintering temperature, sintering time, and molding pressure all decreased sample porosity. Optimum conditions were as follows: nanopowder content of 20%, molding pressure of 200MPa, sintering temperature of 1400°C, and sintering time of 6h.