Abstract: A multi-product supply chain consisting of manufacturers, main suppliers and backup suppliers was analyzed with consideration of supply disruption. And Bertsimas' robust optimization method based on interval analysis was used to describe selling price uncertainty. Under the condition of the manufacturer's profit, the main supplier's profit and the backup supplier's profit maximization, the designed robust model could resist certain uncertainty. Numerical results showed that the proposed model is "robust" when the selling price changes within a certain range.