Journal of Northeastern University Natural Science ›› 2015, Vol. 36 ›› Issue (8): 1097-1101.DOI: 10.12068/j.issn.1005-3026.2015.08.008

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Pathology Simulation of Short QT Syndrome Based on an Improved Model of Ventricular Myocytes

LIU Ji-hong1, 2, LIN Yang2, LIN Hai-ye2   

  1. 1. School of Information Science & Engineering, Northeastern University, Shenyang 110819, China; 2.Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang 110819, China.
  • Received:2014-06-23 Revised:2014-06-23 Online:2015-08-15 Published:2015-08-28
  • Contact: LIU Ji-hong
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Abstract: Based on the data of the existing human ventricular cell model, a one-dimensional ventricular cell model is established. The pseudo ECG, action potentials for the endocardium cell, the mid-myocardium cell and the epicardium cell are simulated. The cycle simulation is carried out based on the established model, the parameters in the model are revised according to the problems encountered in the simulation process. It can be seen by comparing the existed experiment data with the simulation results that the improved model is reasonable and reliable. The KCNJ2-correlated short QT syndrome pathological conditions is also simulated by the improved model and the model proposed is validated.

Key words: pathology simulation, ion channel, action potential duration, membrane conductance, short QT syndrome

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