Effect of Celecoxib on Electrophysiological Property of Cardiac Sodium Channel Nav1.5
SUN Jian-fang1, XU Yi-jia2, WANG Zhan-you1
1. School of Life and Health Sciences, Northeastern University, Shenyang 110169, China; 2. School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang 110016, China.
SUN Jian-fang, XU Yi-jia, WANG Zhan-you. Effect of Celecoxib on Electrophysiological Property of Cardiac Sodium Channel Nav1.5[J]. Journal of Northeastern University Natural Science, 2019, 40(3): 452-456.
[1]Flower R J.The development of COX2 inhibitors [J].Nature Reviews Drug Discovery,2003,2(3):179-191. [2]Solomon S D,Wittes J,Finn P V,et al.Cardiovascular risk of celecoxib in 6 randomized placebo-controlled trials:the cross trial safety analysis [J].Circulation,2008,117(16):2104-2113. [3]Park S Y,Kim T H,Kim H I,et al.Celecoxib inhibits Na+ currents in rat dorsal root ganglion neurons [J].Brain Research,2007,1148:53-61. [4]Ekberg J,Adams D J.Neuronal voltage-gated sodium channel subtypes:key roles in inflammatory and neuropathic pain [J].The International Journal of Biochemistry and Cell Biology,2006,38(12):2005-2010. [5]Payandeh J,Gamal El-Din T M,Scheuer T,et al.Crystal structure of a voltage-gated sodium channel in two potentially inactivated states [J].Nature,2012,486(7401):135-139. [6]Clancy C E,Tateyama M,Liu H,et al.Non-equilibrium gating in cardiac Na+ channels:an original mechanism of arrhythmia [J].Circulation,2003,107(17):2233-2237. [7]Moreau A,Keller D I,Huang H,et al.Mexiletine differentially restores the trafficking defects caused by two brugada syndrome mutations [J].Frontiers in Pharmacology, 2012,3:62. [8]Veldkamp M W,Wilders R,Baartscheer A,et al.Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families [J].Circulation Research,2003,92(9):976-983. [9]Probst V,Kyndt F,Potet F,et al.Haploinsufficiency in combination with aging causes SCN5A-linked hereditary Lenègre disease [J].Journal of the American College Cardiology, 2003,41(4):643-652. [10]Olson T M,Michels V V,Ballew J D,et al.Sodium channel mutations and susceptibility to heart failure and atrial fibrillation [J].JAMA,2005,293(4):447-454. [11]Blechschmidt S,Haufe V,Benndorf K,et al.Voltage-gated Na+ channel transcript patterns in the mammalian heart are species-dependent [J].Progress in Biophysics and Molecular Biology,2008,98(2/3):309-318. [12]Liu Z R,Tao J,Dong B Q,et al.Pharmacological kinetics of BmK AS,a sodium channel site 4-specific modulator on Nav1.3 [J].Neuroscience Bulletin,2012,28(3):209-221. [13]Weber A,Casini A,Heine A,et al.Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib:new pharmacological opportunities due to related binding site recognition [J].Journal of Medicinal Chemistry,2004,47(3):550-557. [14]Krum H,Liew D,Aw J,et al.Cardiovascular effects of selective cyclooxygenase-2 inhibitors [J].Expert Review of Cardiovascular Therapy,2004,2(2):265-270. [15]Macías A,Moreno C,Moral-Sanz J,et al.Celecoxib blocks cardiac Kv1.5,Kv4.3 and Kv7.1(KCNQ1)channels:effects on cardiac action potentials [J].Journal of Molecular and Cellular Cardiology,2010,49(6):984-992. [16]Frolov R V,Ignatova I I,Singh S.Inhibition of HERG potassium channels by celecoxib and its mechanism [J].PLoS One,2011,6(10):e26344. [17]Kim S H,Song S H,Kim S G,et al.Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NF-kappaB as a possible target [J].Journal of Cancer Research and Clinical Oncology,2004,130(9):551-560. [18]Zuo C H,Li Z R,Zhou X,et al.Inhibitory effects of cyclooxygenase-2 inhibitor celecoxib on growth and angiogenesis of human liver cancer HepG2 cell xenografts in small nude mice [J].Chinese Journal of Cancer,2006,25(4):414-420.