Study on Morphology of Red Blood Cell in Micro-channel Towards Vessel-on-Chip

doi:10.12068/j.issn.1005-3026.2023.06.019

Abstract

Abstract: Red blood cell (RBC)， undertaking the significant work of oxygen transport to maintain human life， could shuttle spindly capillaries by their own stretching and contractile properties due to their biconcave discoid shape and hyperelastic responses. In this paper， the coupled fluid-solid module in finite element software COMSOL was used to study the dynamic simulation of RBC when the three factors， including capillary width， plasma viscosity， and blood flow rate were considered. The results implied that the RBC could easily pass through capillary with hole size of 3 μm， and the aqueous shear stress was 4.5 times greater than that in the capillary with 6 μm hole size. Meanwhile， the plasma viscosity of 5.5 mPa·s induced parachute-like formation of RBC. Furthermore， biconcave structure in the center gradually disappeared and turned into bulge along the flow direction. With regard to the study on fluidic velocities in T-shaped and Y-shaped micro-channel， both results indicated that the asymmetric structure caused the falcate shape of RBC. In addition， the higher fluidic velocity in the other branch channel， the easier the convergence leaded to the disappearance of falcate shape and the rod posture lying flat flowing in the solution.

Key words: vessel-on-chip; red blood cell (RBC); hydrodynamics; hyperelastic material; COMSOL

CLC Number:

TN492， TQ460.1

HU Sheng， YE Jun-yan， ZHAO Yong. Study on Morphology of Red Blood Cell in Micro-channel Towards Vessel-on-Chip[J]. Journal of Northeastern University(Natural Science), 2023, 44(6): 906-912.

References

[1]Czerwinska J，Wolf S M，Mohammadi H，et al.Red blood cell aging during storage，studied using optical tweezers experiment［J］.Cellular and Molecular Bioengineering，2015，8(2):258-266.
[2]Mignon T，Mendez S A.Theoretical investigation of the frisbee motion of red blood cells in shear flow［J］.Mathematical Modelling of Natural Phenomena，2021，16:1-28.
[3]戚晓菁，李学进.微流控芯片技术在血细胞变形和流动性分析研究中的应用进展［J］.实验流体力学，2020，34(2):1-10.(Qi Xiao-jing，Li Xue-jin.Research progress on mechanical and flow properties of blood cells in microcirculation using microfluidic devices［J］.Journal of Experiments in Fluid Mechanics，2020，34(2):1-10.)
[4]Ni A，Cheema T A，Kwak M K，et al.Two-dimensional numerical simulation of the red blood cell floating in a plasma-alcohol solution through stenosis in a microvessel［J］.The Korea-Australia Rheology Journal，2014，26(3):293-301.
[5]Ni A，Cheema T A，Park C W.Numerical investigation on the structural characteristics of multiple RBCs in a stenotic microcapillary under plasma-alcohol solution［J］.The Korea-Australia Rheology Journal，2015，27(2):163-171.
[6]Ye H L，Shen Z Q，Li Y.Shape-dependent transport of microparticles in blood flow:from margination to adhesion［J］.Journal of Engineering Mechanics，2019，145(4):1-18.
[7]Cetin A，Sahin M.A monolithic fluid-structure interaction framework applied to red blood cells［J］.International Journal for Numerical Methods in Biomedical Engineering，2019，35(2):e3171.1-e3171.24.
[8]Taraconat P，Gineys J P，Isebe D，et al.Numerical simulation of deformable particles in a coulter counter［J］.International Journal for Numerical Methods in Biomedical Engineering，2019，35(11):1-22.
[9]Jiao Y Y，He Y，Jiao F.Two-dimensional simulation of motion of red blood cells with deterministic lateral displacement devices［J］.Micromachines，2019，10(6):1-15.
[10]Liu Z X，Liu H C，Huang D M，et al.The immersed Boundary-lattice Boltzmann method parallel model for fluid-structure interaction on heterogeneous platforms［J］.Mathematical Problems in Engineering，2020，2020:1-13.
[11]张朦，孟晓辰，祝连庆.基于动态显微成像的红细胞多角度形态学分析方法［J］.光学技术，2021，47(4):417-421.(Zhang Meng，Meng Xiao-chen，Zhu Lian-qing.Multi-angle morphological analysis of red blood cells based on dynamic microscopic imaging［J］.Optical Technique，2021，47(4):417-421.)
[12]Wang Y，Sang J，Ao R，et al.Numerical simulation of deformed red blood cell by utilizing neural network approach and finite element analysis［J］.Computer Methods in Biomechanics and Biomedical Engineering，2020，23(15):1190-1200.
[13]Evans E，Fung Y C.Improved measurements of the erythrocyte geometry［J］.Microvascular Research，1972，4(4):335-347.
[14]王带领，谭建平，程立志，等.基于液固耦合的光镊拉伸红细胞变形特性［J］.中国医学物理学杂志，2017，34(4):404-409.(Wang Dai-ling，Tan Jian-ping，Cheng Li-zhi，et al.Deformation of red blood cells stretching by optical tweezers based on fluid-structure interaction［J］.Chinese Journal of Medical Physics，2017，34(4):404-409.)(上接第905页)
[23]周爱民，余粤.基于流动性囤积视角的银行间流动性风险研究——以2013年“钱荒”为例［J］.金融论坛，2019，24(10):15-23.(Zhou Ai-min，Yu Yue.A research on interbank liquidity risk from the perspective of liquidity hoarding—a case study of “Money Shortage” in 2013［J］.Finance Forum，2019，24(10):15-23.)
[24]苑莹，王海英，庄新田.基于非线性相依的市场间金融传染度量——测度2015年中国股灾对重要经济体的传染效应［J］.系统工程理论与实践，2020，40(3):545-558.(Yuan Ying，Wang Hai-ying，Zhuang Xin-tian.Financial contagion measurement between nonlinear inter-dependent markets: detecting the contagion effects of Chinese stock market crash in 2015 on the world’s important economies［J］.Systems Engineering — Theory & Practice，2020，40(3):545-558.)
[25]Li Y，Zhuang X，Wang J，et al.Analysis of the impact of Sino-US trade friction on China’s stock market based on complex networks［J］.The North American Journal of Economics and Finance，2020，52:101185.
[26]Li Z，Zhou Q，Chen M，et al.The impact of COVID-19 on industry-related characteristics and risk contagion［J］.Finance Research Letters，2021，39: 101931.