Abstract: The strength analysis of a bogie frame under all load conditions was carried out according to the UIC615-4 code, and the stress response of the dangerous point under the most dangerous load condition was obtained. The simulation samples of random parameters and the stress of the dangerous point were obtained by the Latin hypercube sampling method and experiment design, and the explicit expression of the stress response about random variabes was obtained by the nonlinear mapping function training of a BP neurd network. The reliability and reliability sensitivity of the bogie frame were analyzed with the random perturbation technique, first order second moment method and matrix differential method. The work may provide guidance to the load conditions optimization.