Abstract: At present， the domestic bioethics research tends to break away from “authenticity”， and lacks the “thoroughness” of thinking based on “authenticity” in real life. Therefore， it calls for a new ethical methodology to deal with the ethical challenges of gene editing technology more thoroughly and effectively. Ethical reflection must be based on the “authenticity” of the complexity and uncertainty brought by gene editing technology， and fully considers the limitations of human rationality. On this basis， we should focus on the multiple overlapping and complex relationships between the development of gene editing technology and core ethical issues of great subversion and urgency such as human health， fairness， justice and human self-image. The human existence situation and the change of moral philosophy caused by technology should be the core issues of ethical reflection， so as to maintain the characteristics of philosophical speculation， establish a new ethical cognition and construction schema， and then try to explore the new form of ethical norms to reasonably regulate the development of gene editing technology.

Key words: gene editing technology; complexity; uncertainty; ethical norm