Abstract: Intra-party political supervision is the fundamental supervision of the party， and determines the success and efficiency of the intra-party supervision. Strengthening the practice of intra-party political supervision in the new era is the inevitable requirement for the development of Marxist intra-party supervision thought and practice， as well as the practical requirement for the party's political construction and political supervision. Clarifying the wrong understanding of the intra-party supervision by the Commission for Discipline Inspection is the prerequisite for further promoting the intra-party supervision. A thorough understanding of the opportunities for the intra-party supervision by Discipline Inspection Commission and the challenges faced by the political discipline and rules， political orientation and political stance， political culture and political life are the bases for strengthening the intra-party supervision by Commission for Discipline Inspection and exploring effective strategies. The path of the intra-party supervision by the Commission for Discipline Inspection in the new era is to clarify the functional orientation， improve the leadership system， deepen the reform of the inspection system， and straighten out the relationship between itself and other supervision institutions.

Key words: new era, Commission for Discipline Inspection, intra-party political supervision, principal responsibility