东北大学学报:自然科学版 ›› 2019, Vol. 40 ›› Issue (12): 1695-1699.DOI: 10.12068/j.issn.1005-3026.2019.12.005

• 信息与控制 • 上一篇    下一篇

基于Lognormal函数的脉搏波分解可行性研究

王璐1, 陈雪玮2, 郝丽玲2, 徐礼胜2,3   

  1. (1.东北大学 计算机科学与工程学院, 辽宁 沈阳110169; 2. 东北大学 医学与生物信息工程学院, 辽宁 沈阳110169;3.沈阳东软智能医疗科技研究院有限公司, 辽宁 沈阳110167)
  • 收稿日期:2019-02-12 修回日期:2019-02-12 出版日期:2019-12-15 发布日期:2019-12-12
  • 通讯作者: 王璐
  • 作者简介:王璐(1980-),女,辽宁沈阳人,东北大学副教授; 徐礼胜 (1975-),男,安徽安庆人,东北大学教授,博士生导师.
  • 基金资助:
    国家自然科学基金资助项目(61773110,61701099); 辽宁省自然科学基金资助项目(20170540312); 沈阳东软智能医疗科技研究院有限公司开放课题基金资助项目(NRIHTOP1801); 中央高校基本科研业务费专项资金资助项目(N181604006).

Feasibility Research of Pulse Wave Decomposition Based on Lognormal Function

WANG Lu1, CHEN Xue-wei2, HAO Li-ling2, XU Li-sheng2,3   

  1. 1. School of Computer Science & Engineering, Northeastern University, Shenyang 110169, China; 2. School of Medicine & Biological Information Engineering, Northeastern University, Shenyang 110169, China; 3. Neusoft Research of Intelligent Healthcare Technology, Co., Ltd., Shenyang 110167, China.
  • Received:2019-02-12 Revised:2019-02-12 Online:2019-12-15 Published:2019-12-12
  • Contact: XU Li-sheng
  • About author:-
  • Supported by:
    -

摘要: 探讨利用Lognormal(对数正态)函数构建血流流量波进行脉搏波分解的可行性.研究对象为23名健康在校大学生,利用无创主动脉脉搏分析仪(AtCor Medical SphygmoCor)获取无创主动脉脉搏波形.分别利用Lognormal函数和三角波函数构建血流波形,采用阻抗分析技术将主动脉压力波形分解为前向波和反向波并计算反射幅度(RMlog,RMtri)、反射指数(RIlog,RItri),然后对参数进行Bland-Altman法分析和回归分析.两种方法计算的RM,RI一致性良好,其回归方程分别为:RMlog=1.009RMtri-0.007,RIlog=1.008RItri-0.004;RMlog和RMtri显著相关(r=0.999; P<0.001),RIlog和RItri显著相关(r=0.999; P<0.001),且从波形上分析,基于Lognormal函数的脉搏波分解较三角波更好.因此,基于Lognormal函数对主动脉压力波形分解是可行的,而且效果优于三角波函数分解的结果.

关键词: 脉搏波, 波形分解, 阻抗分析, 回归分析

Abstract: The feasibility of decomposing pulse wave was evaluated by constructing the blood flow wave based on the Lognormal function. Twenty-three healthy subjects were studied and their noninvasive aortic pulse waves were acquired by using a noninvasive aortic pulse analyzer (AtCor Medical SphygmoCor). The Lognormal function and the triangle function are applied respectively for constructing the blood flow wave, and aortic pressure waveform is decomposed into forward and backward waves by means of the impedance analysis. The reflection parameters including reflection amplitude (RMlog, RMtri) and reflection index (RIlog, RItri) are then calculated. Meanwhile, these parameters are analyzed by the Bland-Altman method and the regression analysis. The estimation of RM and RI has high consistency for these two methods, and their regression equations are RMlog=1.009RMtri-0.007 and RIlog=1.008RItri-0.004, respectively. RMlog has significantly positive correlation with RMtri (r=0.999; P<0.001), and RIlog has significantly positive correlation with RItri (r=0.999; P<0.001). Therefore, it is feasible to decompose the aortic pressure waveform based on the Lognormal function and the performance is better than that of the triangle function.

Key words: pulse wave, wave decomposition, impedance analysis, regression analysis

中图分类号: