Quantitative Analysis of Pharmacokinetic Parameters Using Clinical Lung Dynamic ContrastEnhanced MR Image

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Journal of Northeastern University ›› 2013, Vol. 34 ›› Issue (10): 1512-1516.DOI: -

• Biologic Engineering • Previous Articles Next Articles

Quantitative Analysis of Pharmacokinetic Parameters Using Clinical Lung Dynamic ContrastEnhanced MR Image

ZHONG Yi¹， LI Zhiyong²， HU Jiani³， KANG Yan^1,4

1. School of SinoDutch Biomedical & Information Engineering， Northeastern University， Shenyang 110819， China; 2. First Affiliated Hospital， Dalian Medical University， Dalian 116011， China; 3. Medical School， Wayne State University， Detroit 48202， United States; 4. Key Laboratory of Medical Image Computing， Ministry of Education， Northeastern University， Shenyang 110819， China.

Received:2012-12-25 Revised:2012-12-25 Online:2013-10-15 Published:2013-05-24
Contact: KANG Yan
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Abstract

Abstract: Based on the dynamic contrastenhanced MRI (DCEMRI) data routinely acquired from a clinical lung， a new method called FCMB RR was proposed for quantitative analysis. This method was based on the reference region model (RR)， and combined with fuzzy Cmean (FCM) and BSpline curve fitting techniques. The proposed FCMB RR method not only solved the limitation of complex blood supply system， but also reduced the effect of noise on the quantitative analysis result. 5 patients with pathologically proven lung cancer were examined using the proposed FCMB RR method to demonstrate the feasibility and effectiveness. A significant difference (P<001) in Ktransbetween tumor tissue and normal tissue was found. It could be concluded that the proposed FCMB RR method could be used for quantitative analysis of typical clinical lung DCEMRI data， and the Ktrans information has reference value for treatment and assesses the lung cancer.

Key words: lung DCEMRI, reference region model, pharmacokinetic parameters, lung cancer, FCM

CLC Number:

R4452

ZHONG Yi， LI Zhiyong， HU Jiani， KANG Yan. Quantitative Analysis of Pharmacokinetic Parameters Using Clinical Lung Dynamic ContrastEnhanced MR Image[J]. Journal of Northeastern University, 2013, 34(10): 1512-1516.

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Quantitative Analysis of Pharmacokinetic Parameters Using Clinical Lung Dynamic ContrastEnhanced MR Image

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