Abstract: The optimization sequence for the safe and effective mining of deep and largescale ore body under high stress environment was studied. Five mining sequences for room and four mining sequences for the pillar have been put forward according to a reasonable production capacity， technical and economic indicators， and are used for establishing the numerical models of FLAC3D . The results show that， among the five room mining sequences the optimal mining sequence is to extract ore rooms 1#， 5#， 9#， 16# and 12# and then followed by ore rooms 3#， 7#， 10#， 14# and 18#， where the stress concentration is the lowest and the displacement variation is smallest. The optimal mining sequence for the pillars is that the pillars 2#， 6#， 11#， 15# in panel mining are firstly extracted and then followed by pillars 4#， 8#， 13#， 17#， where the stress concentration is the lowest. To compare the regular pattern of stress release and the variation of displacement under different schemes， it is observed that after mining stopes of the panel， compressive stress concentration moves to the rib pillar of the central panel， which will be harmful to the roadway of rib pillars. Therefore， support in this area should be strengthened.

Key words: deep large size orebody, subsequent bockfill, mining sequence, rock stability, high stress