Abstract: Simulating cardiac electrophysiology activities through the computer can economically and safely develop the treatment medicine of heart disease. Based on the mathematical model of myocardial cell ion channels， a myocyte ion channels functional simulation platform was achieved， including action potentials for Purkinje fibres cell， the endocardium cell， the midmyocardium cell and the epicardium cell. Pathological conditions were also simulated on the four kinds of cells in the designed system. By analyzing the normal and pathological simulation results， it is showed that the simulation results are consistent with the actual experimental data. The simulation system is reliable.

Key words: cardiac myocyte, ion channel, heart failure, mathematical model, cardiac functional simulation