Corrosion Resistance and Cytotoxicity of Medical Degradable Mg-3Zn-0.5Sr Alloy

doi:10.12068/j.issn.1005-3026.2018.07.013

Abstract

Abstract: The hydroxyapatite (HA) coating was prepared on the surface of Mg-3Zn-0.5Sr alloy by bionic method. The morphology and structure of the coating were characterized by SEM， EDS and XRD. Electrochemical and immersion corrosion experiments were carried out to study the degradation of the alloy and cytotoxicity experiments were also subjected to the HA-coated and uncoated Mg alloy samples. The results show that a dense HA layer with the thickness of 30~40μm can be deposited on the surface of the Mg-3Zn-0.5Sr alloy， which can effectively reduce the degradation rate of this alloy. Relative viability of cells is more than 100% and all samples have cytotoxicity scores of 0， after the cells are cultured in the extracts with the volume fraction of 25% for 4 days.

Key words: Mg-3Zn-0.5Sr alloy, hydro xyapatite, coating, corrosion resistance, cytotoxicity

CLC Number:

ZHANG Ya-jing， GUO Ting-ting， LI Shuai-ping， PENG Wu-xian. Corrosion Resistance and Cytotoxicity of Medical Degradable Mg-3Zn-0.5Sr Alloy[J]. Journal of Northeastern University Natural Science, 2018, 39(7): 976-980.

References

[1]Zheng Y F，Gu X N，Witte F.Biodegradable metals ［J］.Materials Science & Engineering:R，2014，77(2):1-34.
[2]Zreiqat H，Howlett C R，Zannettino A，et al.Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants［J］.Journal of Biomedical Materials Research，2002，62(2):175-184.
[3]Virtanen S.Biodegradable Mg and Mg alloys:corrosion and biocompatibility［J］.Materials Science & Engineering:B，2011，176(20):1600-1608.
[4]Rahim M I，Rohde M，Rais B，et al.Susceptibility of metallic magnesium implants to bacterial biofilm infections［J］.Journal of Biomedical Materials Research Part A，2016，104(6):1489-1499.
[5]Qu H，Wei M.Improvement of bonding strength between biomimetic apatite coating and substrate［J］.Journal of Biomedical Materials Research Part B: Applied Biomaterials，2008，84(2):436-443.
[6]曹楚南.电化学阻抗谱导论［M］.北京:科学出版社，2002:87-113.(Cao Chu-nan.Introduction to electrochemical impedance spectroscopy ［M］.Beijing:Science Press，2002: 87-113.)
[7]Kokubo T，Takadama H.How useful is SBF in predicting in vivo bone bioactivity［J］. Biomaterials，2006，27(15):2907-2915.
[8]宋光铃.镁合金腐蚀与防护［M］.北京:化学工业出版社，2006:94-208.(Song Guang-ling.Corrosion and protection of magnesium alloys［M］.Beijing:Chemical Industry Press，2006:94-208.)
[9]Legeros R Z.Biodegradation and bioresorption of calcium phosphate ceramics［J］.Clinical Materials，1993，14(1):65-88.
[10]Zhang Y，Zhang G，Wei M.Controlling the biodegradation rate of magnesium using biomimetic apatite coating［J］.Journal of Biomedical Materials Research Part B:Applied Biomaterials，2009，89(2):408-414.
[11]Hartwig A.Role of magnesium in genomic stability［J］.Mutation Research，2001， 475(1/2):113.
[12]Vormann J.Magnesium:nutrition and metabolism ［J］.Molecular Aspects of Medicine，2003，24(1/2/3):27-37.
[13]Witte F，Kaese V，Haferkamp H，et al.In vivo corrosion of four magnesium alloys and the associated bone response ［J］.Biomaterials，2005， 26(17):3557-3563.
[14]Yun Y H，Dong Z，Yang D，et al.Biodegradable Mg corrosion and osteoblast cell culture studies ［J］.Materials Science and Engineering:C，2009，29(6):1814-1821.
[15]Saris N E L，Mervaala E，Karppanen H，et al.Magnesium:an update on physiological，clinical and analytical aspects［J］.Clinica Chimica Acta，2000，294(1):1-26.